Numerical Modeling of Synthetic Jets in Quiescent Air with Moving Boundary Conditions

Flow control is a key factor in optimizing the performance of any vehicle moving through fluids. Particularly, in aerodynamics there are many potential benefits for implementing synthetic jets to achieve aircraft designs with less moving parts, uper- maneuverability, and separation control for fuel economy. Piezoelectric synthetic jets are of special interest because of their lightweight and low power consumption. Numerous publications on such jets are available. Actuator properties and boundary conditions relevant to this particular application however are often overlooked. The focus of this project is to numerically model synthetic jets in quiescent air to study the influence of cavity geometry and boundary conditions of the piezoelectric diaphragm on jet velocity. Numerical simulation is performed for two synthetic jet cavities of different height and orifice diameter. The numerical modeling utilizes a turbulent RNG κ ε model and a moving boundary condition with two oscillating deflection profiles, parabolic and logarithmic, applied to the diaphragm. The actuators modeled are typical Bimorph and Thunder piezoelectric actuators. The initial conditions for the actuators are obtained experimentally resulting in 0.396mm and 0.07mm respectively when driven with a sinusoidal wave input at 1524 V/m and 4064 V/m. Although the velocity boundary numerical model gave overall better results than the current moving-boundary numerical model, the moving-boundary model is more accurate since it better approximates the movement of the diaphragm. From an optimizing viewpoint the moving boundary is more suitable to attempt to optimize the design because displacement magnitude of the diaphragm can be measured directly from experiments. For the higher displacement Bimorph actuator, a logarithmic profile matches the experimental results, whereas the parabolic profile provided better results for the relatively small displacement Thunder actuator. It is thus hypothesized that both tested actuators, Bimorph and Thunder, oscillate according to the specified logarithmic and parabolic profile respectively. Cavity height was briefly investigated for the Bimorph actuator. Results show that cavity height did not make a difference in the centerline velocity for the numerical model. The model fails to consider the important effect of the dynamic coupling of the actuator displacement and the pressure that develops inside the cavity. The pressure values obtained are comparable to the theoretical blocking pressure for the Bimorph in the cavity. The results of this study show that jet formation and development has unique characteristics for each actuator and cavity configuration. The smaller orifice cavity configuration produced a faster, longer, thinner jet with larger vortices than the bigger orifice. During max expulsion, t = 0.25T, and max ingestion, t = 0.75T, a low-pressure area localized at the corners of the orifice, inlet and exit respectively, were observed. All cavity configurations passed all three known jet formation criterions that include, Lo/Do\u3e1, Re \u3e 50, and Re/S2 \u3e 0.16

Radial-Electric-Field Piezoelectric Diaphragm Pumps

In a recently invented class of piezoelectric diaphragm pumps, the electrode patterns on the piezoelectric diaphragms are configured so that the electric fields in the diaphragms have symmetrical radial (along-the-surface) components in addition to through-the-thickness components. Previously, it was accepted in the piezoelectric-transducer art that in order to produce the out-of-plane bending displacement of a diaphragm needed for pumping, one must make the electric field asymmetrical through the thickness, typically by means of electrodes placed on only one side of the piezoelectric material. In the present invention, electrodes are placed on both sides and patterned so as to produce substantial radial as well as through-the-thickness components. Moreover, unlike in the prior art, the electric field can be symmetrical through the thickness. Tests have shown in a given diaphragm that an electrode configuration according to this invention produces more displacement than does a conventional one-sided electrode pattern. The invention admits of numerous variations characterized by various degrees of complexity. Figure 1 is a simplified depiction of a basic version. As in other piezoelectric diaphragm pumps of similar basic design, the prime mover is a piezoelectric diaphragm. Application of a suitable voltage to the electrodes on the diaphragm causes it to undergo out-of-plane bending. The bending displacement pushes a fluid out of, or pulls the fluid into, a chamber bounded partly by the diaphragm. Also as in other diaphragm pumps in general, check valves ensure that the fluid flows only in through one port and only out through another port

Parametric field modeling for the LHC main magnets in operating conditions

The first beam injections and current ramps in the LHC will require a prediction of the settings of the magnet current as well as the main correctors. For this reason we are developing a parametric model of the magnetic field generated by the LHC magnets that will provide the field dependence on current, ramp-rate, time, and history. The model of the field is fitted on magnetic field measurements performed during the acceptance tests of the magnets before their installation in the machine. In this paper we summarize the different steps necessary to select the relevant data and identify the parameters: the data extraction, the filtering and the validation of the measurements, and the fitting procedure that is used to obtain the parameters from the experimental results. The main result reported is a summary of the value of the parameters obtained with the above procedure, and describing the behavior of the magnetic field in the LHC main dipoles and quadrupoles.peer-reviewe

The IsoDAR high intensity H2+ transport and injection tests

This technical report reviews the tests performed at the Best Cyclotron Systems, Inc. facility in regards to developing a cost effective ion source, beam line transport system, and acceleration system capable of high H[subscript 2][superscript +] current output for the IsoDAR (Isotope Decay At Rest) experiment. We begin by outlining the requirements for the IsoDAR experiment then provide overviews of the Versatile Ion Source (VIS), Low Energy Beam Transport (LEBT) system, spiral inflector, and cyclotron. The experimental measurements are then discussed and the results are compared with a thorough set of simulation studies. Of particular importance we note that the VIS proved to be a reliable ion source capable of generating a large amount of H[subscript 2][superscript +] current. The results suggest that with further upgrades, the VIS could potentially be a suitable candidate for IsoDAR. The conclusion outlines the key results from our tests and introduces the forthcoming work this technical report has motivated.National Science Foundation (U.S.) (PHY-1148134)Massachusetts Institute of Technology (Seed Fund)Massachusetts Institute of Technology (Bose Fellowship

Spin-Charge Separation, Anomalous Scaling and the Coherence of Hopping in exactly solved Two Chain Models

The coherence of transport between two one-dimensional interacting Fermi liquids, coupled by single particle hopping and interchain interaction, is examined in the context of two exactly soluble models. It is found that the coherence of the inter-chain hopping depends on the interplay between inter-chain hopping and inter-chain interaction terms, and not simply on the ground state spectral properties of an isolated chain. Specifically, the splitting of levels in associated with interchain hopping in a $g_4$ soluble model is found to be enhanced by the introduction of interchain interaction. It is also shown that, for an exactly solvable model with both $g_2$ and $g_4$ interactions, coherent interchain hopping coexists with anomalous scaling and non-Fermi liquid behavior in the chain direction.Comment: Two postscript figure

Determining the electron-phonon coupling in superconducting cuprates by resonant inelastic x-ray scattering: Methods and results on Nd1+xBa2-xCu3O7-δ

The coupling between lattice vibration quanta and valence electrons can induce charge-density modulations and decisively influence the transport properties of materials, e.g., leading to conventional superconductivity. In high-critical-temperature superconductors, where electronic correlation is the main actor, the actual role of electron-phonon coupling (EPC) is being intensely debated theoretically and investigated experimentally. We present an in-depth study of how the EPC strength can be obtained directly from resonant inelastic x-ray scattering (RIXS) data through the theoretical approach derived by Ament et\ua0al. [Europhys. Lett. 95, 27008 (2011)]. The role of the model parameters (e.g., phonon energy ω0, intermediate state lifetime 1/Γ, EPC matrix element M, and detuning energy Ω) is thoroughly analyzed, providing general relations among them that can be used to make quantitative estimates of the dimensionless EPC g=(M/ω0)2 without detailed microscopic modeling. We then apply these methods to very high-resolution Cu L3-edge RIXS spectra of three Nd1+xBa2−xCu3O7−δ films. For the insulating antiferromagnetic parent compound, the value of M as a function of the in-plane momentum transfer is obtained for Cu-O bond-stretching (breathing) and bond-bending (buckling) phonon branches. For the underdoped and the nearly optimally doped samples, the effects of Coulomb screening and of charge-density-wave correlations on M are assessed. In light of the anticipated further improvements of the RIXS experimental resolution, this work provides a solid framework for an exhaustive investigation of the EPC in cuprates and other quantum materials

Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men

Controversy surrounds the use of PSA as a biomarker for prostate cancer detection, leaving an unmet need for a novel biomarker in this setting; urinary EN2 may identify individuals with clinically relevant prostate cancer. Male BRCA1 and BRCA2 mutation carriers are at increased risk of clinically significant prostate cancer and may benefit from screening. Urine samples from 413 BRCA1 and BRCA2 mutation carriers and controls were evaluated. Subjects underwent annual PSA screening with diagnostic biopsy triggered by PSA > 3.0 ng/ml; 21 men were diagnosed with prostate cancer. Urinary EN2 levels were measured by ELISA and had a sensitivity of 66.7% and specificity of 89.3% for cancer detection. There was no statistically significant difference in EN2 levels according to genetic status or Gleason score. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma

Intuitive Visualization and Analysis of Multi-Omics Data and Application to Escherichia coli Carbon Metabolism

Combinations of ‘omics’ investigations (i.e, transcriptomic, proteomic, metabolomic and/or fluxomic) are increasingly applied to get comprehensive understanding of biological systems. Because the latter are organized as complex networks of molecular and functional interactions, the intuitive interpretation of multi-omics datasets is difficult. Here we describe a simple strategy to visualize and analyze multi-omics data. Graphical representations of complex biological networks can be generated using Cytoscape where all molecular and functional components could be explicitly represented using a set of dedicated symbols. This representation can be used i) to compile all biologically-relevant information regarding the network through web link association, and ii) to map the network components with multi-omics data. A Cytoscape plugin was developed to increase the possibilities of both multi-omic data representation and interpretation. This plugin allowed different adjustable colour scales to be applied to the various omics data and performed the automatic extraction and visualization of the most significant changes in the datasets. For illustration purpose, the approach was applied to the central carbon metabolism of Escherichia coli. The obtained network contained 774 components and 1232 interactions, highlighting the complexity of bacterial multi-level regulations. The structured representation of this network represents a valuable resource for systemic studies of E. coli, as illustrated from the application to multi-omics data. Some current issues in network representation are discussed on the basis of this work

A Novel Statistic for Genome-Wide Interaction Analysis

Although great progress in genome-wide association studies (GWAS) has been made, the significant SNP associations identified by GWAS account for only a few percent of the genetic variance, leading many to question where and how we can find the missing heritability. There is increasing interest in genome-wide interaction analysis as a possible source of finding heritability unexplained by current GWAS. However, the existing statistics for testing interaction have low power for genome-wide interaction analysis. To meet challenges raised by genome-wide interactional analysis, we have developed a novel statistic for testing interaction between two loci (either linked or unlinked). The null distribution and the type I error rates of the new statistic for testing interaction are validated using simulations. Extensive power studies show that the developed statistic has much higher power to detect interaction than classical logistic regression. The results identified 44 and 211 pairs of SNPs showing significant evidence of interactions with FDR<0.001 and 0.001<FDR<0.003, respectively, which were seen in two independent studies of psoriasis. These included five interacting pairs of SNPs in genes LST1/NCR3, CXCR5/BCL9L, and GLS2, some of which were located in the target sites of miR-324-3p, miR-433, and miR-382, as well as 15 pairs of interacting SNPs that had nonsynonymous substitutions. Our results demonstrated that genome-wide interaction analysis is a valuable tool for finding remaining missing heritability unexplained by the current GWAS, and the developed novel statistic is able to search significant interaction between SNPs across the genome. Real data analysis showed that the results of genome-wide interaction analysis can be replicated in two independent studies